Zachariae H, Bjerring P
Acta Derm Venereol. 1982;62(5):446-8.
Studies on thirty-six psoriatics revealed no differences in acute liver toxicity of four different intermittent dosage schedules of methotrexate with or without addition of leucovorin, as judged by daily determinations of SGOT for one week. Three patients with psoriatic erythroderma receiving high-dosage methotrexate (100 mg i.v.) with leucovorin rescue responded extremely well to treatment and did not distinguish themselves from the other patients with regard to acute liver toxicity.
对36名银屑病患者的研究表明，通过连续一周每日测定谷草转氨酶（SGOT）来判断，甲氨蝶呤四种不同的间歇给药方案（加或不加亚叶酸）在急性肝毒性方面并无差异。三名接受高剂量甲氨蝶呤（静脉注射100毫克）并采用亚叶酸解救的红皮病型银屑病患者对治疗反应极佳，在急性肝毒性方面与其他患者并无区别。
