Nederman T, Benediktsson G
Acta Radiol Oncol. 1982;21(4):231-4. doi: 10.3109/02841868209134011.
The influence of interferon (IFN) on the growth rate and on the radiation sensitivity of 2 human tumour cell lines was investigated. The 2 glioma cell lines (U-118 MG and U-251 MG) were continuously exposed to IFN (100 U/ml) in the culture medium. Irradiation (3 Gy) was performed either on the first day of IF treatment or on day 14 of IFN treatment. The growth delay induced by the treatments was analysed. The results indicated that IFN had an anti-proliferative effect on the 2 cell lines. However, this effect declined during the treatment and after 2 to 3 weeks of continuous IFN treatment, both cell lines had re-established their original growth rate. IFN did not seem to affect the sensitivity of the cells to radiation. Only an additive effect could be observed.
研究了干扰素（IFN）对两种人类肿瘤细胞系生长速率和辐射敏感性的影响。两种胶质瘤细胞系（U-118 MG和U-251 MG）在培养基中持续暴露于IFN（100 U/ml）。在IF治疗的第一天或IFN治疗的第14天进行照射（3 Gy）。分析了治疗引起的生长延迟。结果表明，IFN对这两种细胞系具有抗增殖作用。然而，在治疗期间这种作用有所下降，并且在连续IFN治疗2至3周后，两种细胞系都重新恢复了其原始生长速率。IFN似乎不影响细胞对辐射的敏感性。仅观察到相加作用。
