Tiwari R K, Bandyopadhyay S K, Chatterjee G C
Acta Vitaminol Enzymol. 1982;4(3):215-20.
Administration of lindane at a dose of 20 mg/kg body weight/day for 15 days to male rats brought about marked growth retardation. Succinic dehydrogenase, Mg2+-ATPase and glucose-6-phosphatase activities were inhibited in different fractions of liver tissues. Mg2+-ATPase, alkaline phosphatase and NADH-dehydrogenase activities were also inhibited in the liver plasma membranes of the lindane treated animals. Stimulation of 5'-nucleotidase activity in liver plasma membrane was observed under lindane intoxication. Supplementation of L-ascorbic acid by separate oral administration to the lindane intoxicated rats neutralized the growth retardation and maintained almost normal values of all the enzymes studied.
以20毫克/千克体重/天的剂量给雄性大鼠施用林丹15天，导致明显的生长迟缓。肝组织不同部分的琥珀酸脱氢酶、Mg2 + -ATP酶和葡萄糖-6-磷酸酶活性受到抑制。林丹处理动物的肝质膜中的Mg2 + -ATP酶、碱性磷酸酶和NADH脱氢酶活性也受到抑制。在林丹中毒情况下，观察到肝质膜中5'-核苷酸酶活性受到刺激。对林丹中毒大鼠单独口服补充L-抗坏血酸可中和生长迟缓，并使所有研究的酶维持几乎正常的值。
