Komarov E V, Fomicheva G K, Rodichev A G
Antibiotiki. 1982;27(9):658-61.
The pH scale of aqueous-alcoholic solutions titrated with aqueous solutions of hydrochloric acid and sodium hydrate was developed. These agents are most frequently used in investigation of the acid and basic transformations of antibiotics. The use of the scale was exemplified with the study of acid and basic properties of gramicidin S containing 2 amino groups in the side chain. Calculation of the constants of protonization of the amino groups of gramicidin S showed their significant differences depending on the solvent nature.
制定了用盐酸水溶液和氢氧化钠水溶液滴定的水 - 醇溶液的pH标度。这些试剂最常用于研究抗生素的酸碱转化。通过研究侧链中含有2个氨基的短杆菌肽S的酸碱性质举例说明了该标度的用途。短杆菌肽S氨基质子化常数的计算表明，其值因溶剂性质不同而有显著差异。
