Berger J
Folia Haematol Int Mag Klin Morphol Blutforsch. 1982;109(4):569-80.
We evaluated changes in blood morphology for detecting acute blood loss in laboratory rats. Haematologic indices which are normally used in investigating drug effects on rat blood morphology were examined. Sublethal acute blood loss (25 ml per kg body weight) modified rat blood morphology in a few minutes; the blood picture was normal within two weeks. Blood drawing (usually up to 10 ml per kg b.w.) can modify rat blood morphology within one week. Erythrocyte counts, haemoglobin concentration and haematocrit decreased earliest, reticulocyte counts were changed longest. Comparing our results and literature data the recovery of blood morphology from acute haemorrhage seems to be more rapid in rats than in men.
我们评估了实验室大鼠血液形态的变化，以检测急性失血情况。对通常用于研究药物对大鼠血液形态影响的血液学指标进行了检查。亚致死性急性失血（每千克体重25毫升）在几分钟内就改变了大鼠的血液形态；两周内血液图像恢复正常。采血（通常每千克体重最多10毫升）可在一周内改变大鼠的血液形态。红细胞计数、血红蛋白浓度和血细胞比容最早下降，网织红细胞计数变化持续时间最长。将我们的结果与文献数据进行比较，大鼠急性出血后血液形态的恢复似乎比人类更快。
