Fouad F M, Aboul-Khair M, Tarazi R C
J Cardiovasc Pharmacol. 1982;4 Suppl 3:S383-6.
The hemodynamic effects of nitrendipine, a new calcium entry blocker, have been evaluated both experimentally and in hypertensive patients. The acute hemodynamic effects (left atrial injection of radioactive microspheres) were studied in normotensive and hypertensive (2K-1 Clip, Goldblatt) Sprague-Dawley rats; two dose levels were used intravenously: 0.3 and 3.0 mg/kg body weight. Arterial blood pressure was reduced in both groups in a dose dependent manner. Cardiac output increased with the higher dose but was reduced with the smaller dose. In humans, nitrendipine was given in a dose of 20 mg b.i.d. for 2 weeks to nine hypertensive patients. The reduction in blood pressure was due to a decrease in systemic resistance (52 +/- 9.7 (SD) to 39 +/- 5.4 u X M2, p less than 0.05); both cardiac output and heart rate response varied among patients (+ 2.1 to -0.97 L/min and + 19 to 4 bpm, respectively). Vasodilators have been previously classified according to predominance of their effects on venous or arterial system. Results of this study suggested that the same vasodilator could fall in one or the other subdivision depending on the dose used and possibly on individual responses.
新型钙通道阻滞剂尼群地平的血流动力学效应已在实验中和高血压患者中进行了评估。在正常血压和高血压（2K-1夹闭，戈德布拉特）的斯普拉格-道利大鼠中研究了其急性血流动力学效应（经左心房注射放射性微球）；静脉内使用了两个剂量水平：0.3和3.0毫克/千克体重。两组的动脉血压均呈剂量依赖性降低。高剂量时心输出量增加，低剂量时心输出量降低。在人体中，给予9名高血压患者20毫克尼群地平，每日两次，共2周。血压降低是由于全身阻力下降（从52±9.7（标准差）降至39±5.4微升×米²，p<0.05）；心输出量和心率反应在患者之间各不相同（分别为+2.1至-0.97升/分钟和+19至4次/分钟）。血管扩张剂以前是根据其对静脉或动脉系统的主要作用进行分类的。本研究结果表明，同一血管扩张剂可能根据所用剂量以及可能的个体反应而归入这一或另一亚类。
