Williams C K, Aderoju E A, Adenle A D, Sekoni G, Esan G J
Acta Haematol. 1982;68(4):329-32. doi: 10.1159/000207003.
3 cases of aplastic anaemia occurring in association with anti-tuberculosis chemotherapy are reported. The patients had been on anti-tuberculosis chemotherapy for 13, 11 and 14 months, respectively, prior to the diagnosis of aplastic anaemia. Agents used included streptomycin, thiacetazone, isoniazid, p-aminosalicylic acid and dimethylcarbazine. Recovery from aplasia did not occur 6. 1.5 and 0.8 months, respectively, after the discontinuation of the suspect myelotoxic agents and despite the use of myelostimulatory agents. All 3 patients died of haemorrhage secondary to thrombocytopenia. The observations are consistent with a protracted and probably irreversible damage of the bone marrow by anti-tuberculosis agent(s) in susceptible individuals.
报告了3例与抗结核化疗相关的再生障碍性贫血病例。在诊断为再生障碍性贫血之前，患者分别接受抗结核化疗13、11和14个月。使用的药物包括链霉素、氨硫脲、异烟肼、对氨基水杨酸和二甲卡巴嗪。在停用可疑的骨髓毒性药物后，尽管使用了骨髓刺激剂，但分别在6、1.5和0.8个月后再生障碍均未恢复。所有3例患者均死于血小板减少继发的出血。这些观察结果表明，抗结核药物对易感个体的骨髓造成了长期且可能不可逆的损害。
