Effect of some antianaphylactic drugs on histamine release from rat mast cells induced by the ionophore A 23 187.

Concerning DSCG and its action on histamine release induced by the ionophore A 23 187, the reported results are controversial; hence we have studied it further. Experiments were performed using mixed peritoneal cells of the rat. Released and residual histamine were measured fluorimetrically. Pyridoxine and disodium cromoglycate reduced histamine release from rat mast cells induced by a) dextran plus phosphatidyl serine and b) the calcium ionophore A 23 187. The relevance of these results to the mechanism of action of the drugs is discussed.