Valenzuela C Y, Harb Z
Am J Hum Genet. 1982 Nov;34(6):925-36.
In the maternity service of a private hospital in Santiago, Chile, 6,974 mother-infant pairs typed for the D-d alleles of the Rh system were collected. In our analysis, all the paris attended from October 1974 to December 1975 and from January 1977 to September 1979 were used. The segregation analysis, made by means of the T mother-child matrix, assuming Hardy-Weinberg equilibrium, reveals that: Rh(-) mothers have a higher rate of admission than do Rh(+) mothers; Rh(+) mothers produce fewer Rh(-) infants than expected; and, with less significance, Rh(-) mothers produce more Rh(+) infants than expected. This leads to a reduction in the proportion of dd individuals from mothers to their children. Ethnic subdivisions of the sample, the period considered, and the extension of the antiisoimmunization therapy do not seem to affect the general pattern of the distortion. The only plausible hypothesis to explain this finding is that selection is not related to the known Rh antigenic specificities. The reduction of the proportion of dd individuals in 1 generation leads us to review models on Rh polymorphism. It seems clear that no classical compensation is possible and d must disappear unless another mechanism maintains it in populations.
在智利圣地亚哥一家私立医院的产科，收集了6974对母婴的Rh系统D - d等位基因分型数据。在我们的分析中，使用了1974年10月至1975年12月以及1977年1月至1979年9月期间就诊的所有母婴对。通过T母子矩阵进行的分离分析，假设处于哈迪 - 温伯格平衡，结果显示：Rh(-)母亲的入院率高于Rh(+)母亲；Rh(+)母亲所生Rh(-)婴儿数量少于预期；并且，显著性稍低的是，Rh(-)母亲所生Rh(+)婴儿数量多于预期。这导致从母亲到孩子的dd个体比例降低。样本的种族细分、所考虑的时期以及抗同种免疫治疗的范围似乎都不会影响这种畸变的总体模式。解释这一发现的唯一合理假设是，选择与已知的Rh抗原特异性无关。一代中dd个体比例的降低促使我们重新审视Rh多态性模型。很明显，不存在经典的补偿机制，除非有其他机制在人群中维持它，否则d必然会消失。
