Botez M I, Young S N, Bachevalier J, Gauthier S
Ann Neurol. 1982 Nov;12(5):479-84. doi: 10.1002/ana.410120512.
Indoles were measured in cerebrospinal fluid (CSF) from control patients, from patients suffering from folate deficiency, and from patients with vitamin B12 deficiency. The folate-deficient patients were classified according to whether they exhibited a neuropsychiatric syndrome, consisting of organic mental changes, polyneuropathy, and depression, which responded to folate administration. CSF 5-hydroxyindoleacetic acid was low in the vitamin B12-deficient patients and in those folate-deficient patients whose symptoms were not related to folate deficiency. CSF 5-hydroxyindoleacetic acid returned to normal with folate treatment in the patients exhibiting folate-responsive neuropsychiatric signs. The data indicate a close association between folate-responsive neuropsychiatric symptoms and changes in 5-hydroxytryptamine metabolism in the central nervous system.
对对照组患者、叶酸缺乏患者以及维生素B12缺乏患者的脑脊液（CSF）中的吲哚进行了测量。叶酸缺乏患者根据是否表现出一种神经精神综合征进行分类，该综合征包括器质性精神改变、多发性神经病和抑郁症，这些症状对叶酸给药有反应。维生素B12缺乏患者以及那些症状与叶酸缺乏无关的叶酸缺乏患者的脑脊液5-羟吲哚乙酸水平较低。在表现出叶酸反应性神经精神体征的患者中，叶酸治疗后脑脊液5-羟吲哚乙酸恢复正常。数据表明叶酸反应性神经精神症状与中枢神经系统中5-羟色胺代谢变化之间存在密切关联。
