Saxinger C, Schetters H
Cancer Lett. 1982 Sep;16(3):267-72. doi: 10.1016/0304-3835(82)90006-4.
Tissues obtained at necropsy from a 7 year old male gibbon ape with malignant lymphoma and leukemia were analyzed by electron microscopic, immunological and enzymological techniques to determine the comparative localization of tumor cells and virus throughout the body. In general, the different assays correlated well; the reverse transcriptase (RT) assay and p30 radioimmunoassay (RIA) being the most sensitive, although the RT assay was able to detect activity in one tissue scored negative by p30 RIA. Tissues were infiltrated with tumor cells to varying degrees which correlated well with the level of virus markers in most cases with the exception of the liver and kidney. In these 2 organs there was marked infiltration of free virus and tumor cells but there was no evidence of virus infection or production by these cells.
对一只患有恶性淋巴瘤和白血病的7岁雄性长臂猿尸检时获取的组织，采用电子显微镜、免疫学和酶学技术进行分析，以确定肿瘤细胞和病毒在全身的相对定位。总体而言，不同检测方法的结果相关性良好；逆转录酶（RT）检测和p30放射免疫分析（RIA）最为灵敏，不过RT检测能在一个被p30 RIA判定为阴性的组织中检测到活性。组织中不同程度地浸润着肿瘤细胞，在大多数情况下，这与病毒标志物水平密切相关，但肝脏和肾脏除外。在这两个器官中，存在大量游离病毒和肿瘤细胞浸润，但没有证据表明这些细胞发生了病毒感染或产生病毒。
