Lembeck F, Donnerer J, Barthó L
Eur J Pharmacol. 1982 Nov 19;85(2):171-6. doi: 10.1016/0014-2999(82)90462-9.
The substance P (SP) analogues [D-Pro2, D-Phe7, D-Trp9]SP and [D-Pro2, D-Trp7,9]SP, which have been reported to be SP antagonists, inhibited the vasodilation and plasma extravasation induced by antidromic stimulation of the saphenous nerve or by i.a. infusion of SP. Somatostatin inhibited the vasodilatation and plasma extravasation induced by saphenous nerve stimulation, but had no effect on the vascular responses to i.a. infused SP. The opiate agonist [D-Met2, Pro5]enkephalinamide inhibited the vasodilation evoked by antidromic nerve stimulation in a naloxone reversible manner, but did not change the effect of i.a. infusion of SP. Calcitonin and caerulein had no effect on neurogenic vasodilatation. These results further support the concepts that neurogenic vasodilatation and plasma extravasation are mediated by SP, and that somatostatin and opiates inhibit the release of SP from peripheral sensory nerve endings.
据报道，物质P（SP）类似物[D - Pro2，D - Phe7，D - Trp9]SP和[D - Pro2，D - Trp7,9]SP为SP拮抗剂，它们可抑制由隐神经逆向刺激或经动脉内注射SP所诱导的血管舒张和血浆外渗。生长抑素可抑制由隐神经刺激所诱导的血管舒张和血浆外渗，但对经动脉内注射SP所引起的血管反应无影响。阿片类激动剂[D - Met2，Pro5]脑啡肽酰胺以纳洛酮可逆的方式抑制由逆向神经刺激所诱发的血管舒张，但不改变经动脉内注射SP的效应。降钙素和蛙皮素对神经源性血管舒张无影响。这些结果进一步支持了以下观点：神经源性血管舒张和血浆外渗由SP介导，生长抑素和阿片类物质可抑制外周感觉神经末梢释放SP。
