Otten U, Rüegg U T, Hill R C, Businger F, Peck M
Eur J Pharmacol. 1982 Dec 3;85(3-4):351-3. doi: 10.1016/0014-2999(82)90225-4.
An experimental autoimmune model was used to study effects of nerve growth factor deprivation on the peptide content of sensory neurones and on pain sensitivity. Rats exposed during development to anti-nerve growth factor antibodies showed an increased threshold towards nociceptive stimuli. These animals also showed a significant decrease in substance P levels in their dorsal root ganglia and spinal cord. These results suggest that substance P-containing primary sensory neurones are involved in certain types of nociception.
采用实验性自身免疫模型研究神经生长因子剥夺对感觉神经元肽含量及疼痛敏感性的影响。在发育过程中接触抗神经生长因子抗体的大鼠对伤害性刺激的阈值升高。这些动物的背根神经节和脊髓中P物质水平也显著降低。这些结果表明，含P物质的初级感觉神经元参与了某些类型的痛觉感受。
