赖氨酸转运RNA2是大鼠体内L-乙硫氨酸的主要作用靶点。
Lysine transfer RNA2 is the major target for L-ethionine in the rat.
作者信息
Kuchino Y, Sharma O K, Borek E
出版信息
Biochemistry. 1978 Jan 10;17(1):144-7. doi: 10.1021/bi00594a021.
PMID:618538
Abstract
Ethionine, a hepatocarcinogen, ethylates macromolecules in vivo especially tRNA of rat liver. When rats were injected with L-[ethyl-3H]ethionine, the tRNA fraction of the liver was found to be labeled. One tRNA with the highest specific activity was purified and identified as lysine-tRNA2.
摘要
乙硫氨酸是一种肝致癌物，它在体内使大分子发生乙基化，尤其是大鼠肝脏的转运核糖核酸（tRNA）。当给大鼠注射L-[乙基-³H]乙硫氨酸时，发现肝脏的tRNA部分被标记。一种比活性最高的tRNA被纯化出来，并被鉴定为赖氨酸-tRNA2。
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