Kuchino Y, Sharma O K, Borek E
Biochemistry. 1978 Jan 10;17(1):144-7. doi: 10.1021/bi00594a021.
Ethionine, a hepatocarcinogen, ethylates macromolecules in vivo especially tRNA of rat liver. When rats were injected with L-[ethyl-3H]ethionine, the tRNA fraction of the liver was found to be labeled. One tRNA with the highest specific activity was purified and identified as lysine-tRNA2.
乙硫氨酸是一种肝致癌物,它在体内使大分子发生乙基化,尤其是大鼠肝脏的转运核糖核酸(tRNA)。当给大鼠注射L-[乙基-³H]乙硫氨酸时,发现肝脏的tRNA部分被标记。一种比活性最高的tRNA被纯化出来,并被鉴定为赖氨酸-tRNA2。