Young K D, Church M K
Int Arch Allergy Appl Immunol. 1983;70(2):138-42. doi: 10.1159/000233311.
Histamine release from human lung fragments, passively sensitized and challenged with antigen under standardized experimental conditions, varied between 0 and 41.2% (mean +/- SD 15.6 +/- 10.0%) in 89 experiments. Over 41 lungs, the mean coefficient of variation for release from 10 to 28 tissue replicates was 21.4% (range 7-44%). Sodium cromoglycate and chlorpromazine were both partial antagonists of histamine release producing, at best, 30-40% inhibition. The cromoglycate analogue, bufrolin, showed similar activity. There was considerable variation in the effects of these drugs both within and between experiments. Salbutamol was a more potent and more effective inhibitor of release but it, too, showed variability. Although theoretically a very appropriate model of allergic asthma, passive anaphylaxis in human lung fragments is quantitatively inconsistent and gives only a gross indication of drug efficacy.
在标准化实验条件下，对人肺组织碎片进行被动致敏并用抗原激发后，组胺释放量在89次实验中为0至41.2%（均值±标准差为15.6±10.0%）。在41个以上的肺组织中，10至28个组织复制品释放量的平均变异系数为21.4%（范围为7 - 44%）。色甘酸钠和氯丙嗪都是组胺释放的部分拮抗剂，最多产生30 - 40%的抑制作用。色甘酸类似物布福罗林表现出相似的活性。这些药物的效果在实验内部和实验之间都有相当大的差异。沙丁胺醇是一种更有效且更具效力的释放抑制剂，但它也表现出变异性。虽然从理论上讲，人肺组织碎片中的被动过敏反应是过敏性哮喘的一个非常合适的模型，但在数量上并不一致，只能粗略地表明药物疗效。
