[Effect of bile salt excess in the duodenal lumen on the enzymatic equipment of pancreatic tissue in the pig].

This study reports the effect of long-term (8 days) addition of bile salts in the duodenal lumen of the pig in which the bile enterohepatic cycle was fully maintained. Seventeen pigs were fitted with permanent fistulae in the bile duct and the duodenum. The bile collected in 9 pigs was returned to the intestine, while that of the other 8 pigs was returned after a 30 p. 100 excess in bile salts, supplied by lyophilized porcine bile, had been added. At the end of the 8-day experimental period, the enzymes were determined in the fresh total pancreatic glands of all the pigs. The results showed no significant differences in lipase, colipase, amylase, chymotrypsin or trypsin activities in either group of animals. The existence of an in vivo relationship between bile salts and colipase secretions is hypothesized.