血红蛋白F与通过色谱法测定的糖化血红蛋白水平评估血糖控制情况

Haemoglobin F and the assessment of glucose control by chromatographically determined HbA1c levels.

作者信息

Svendsen P A, Søegaard U

出版信息

Scand J Clin Lab Invest. 1982 Oct;42(6):535-7. doi: 10.1080/00365518209168125.

DOI:10.1080/00365518209168125

Abstract

HbF and HbA1c-levels were determined in diabetic patients and non-diabetic controls to evaluate the influence of HbF on chromatographically determined HbA1c-levels. No difference in mean HbF was observed between controls and diabetic patients. However, in the combined material, women had a higher mean value (0.31%) than men (0.20%). Estimates of time average blood glucose concentrations (Cglc, mmol/l) were calculated from HbA1c-values in diabetic patients corrected for codetermined HbF. This correction resulted in a difference greater than 1 mmol/l in only 4% of diabetic men and 28% of diabetic women compared to estimates of Cglc from uncorrected HbA1c-results. We conclude, however, that the influence of HbF on chromatographically determined HbA1c-levels in most cases is of minor importance in assessing glucose control in diabetic patients.

摘要

在糖尿病患者和非糖尿病对照中测定了HbF和HbA1c水平，以评估HbF对色谱法测定的HbA1c水平的影响。对照组和糖尿病患者之间未观察到平均HbF有差异。然而，在合并资料中，女性的平均值（0.31%）高于男性（0.20%）。根据校正了共同测定的HbF后的糖尿病患者的HbA1c值，计算时间平均血糖浓度（Cglc，mmol/L）的估计值。与未校正的HbA1c结果得出的Cglc估计值相比，这种校正仅导致4%的糖尿病男性和28%的糖尿病女性的差异大于1 mmol/L。然而，我们得出结论，在大多数情况下，HbF对色谱法测定的HbA1c水平的影响在评估糖尿病患者的血糖控制方面不太重要。