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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lismonde M, Damas J, Remacle-Volon G

Arch Int Physiol Biochim. 1982 Oct;90(3):135-40. doi: 10.3109/13813458209070563.

Injected in the paw of the rat, polymorphonuclear leucocytes do not increase the oedematogen action of bradykinin, but increase the action of lambda carrageenan. 2. This potentiation of carrageenan action is not modified when PG biosynthesis in leucocytes is inhibited by indomethacin or aspirin. It does not appear in rats previously treated by indomethacin or aspirin. 3. Our results suggest that rat polymorphonuclear leucocytes increase the inflammatory reaction, when they are stimulated by carrageenan, by the release of a phospholipase A2 activity which induces PG biosynthesis in rat paw tissues.

将多形核白细胞注射到大鼠爪中，它不会增强缓激肽的致水肿作用，但会增强λ-角叉菜胶的作用。2. 当白细胞中的前列腺素生物合成被吲哚美辛或阿司匹林抑制时，角叉菜胶作用的这种增强不会改变。在先前用吲哚美辛或阿司匹林处理过的大鼠中不会出现这种情况。3. 我们的结果表明，当大鼠多形核白细胞受到角叉菜胶刺激时，它们会通过释放磷脂酶A2活性来增加炎症反应，该活性会诱导大鼠爪组织中的前列腺素生物合成。

Lismonde M, Damas J, Remacle-Volon G

Arch Int Physiol Biochim. 1982 Oct;90(3):135-40. doi: 10.3109/13813458209070563.

Injected in the paw of the rat, polymorphonuclear leucocytes do not increase the oedematogen action of bradykinin, but increase the action of lambda carrageenan. 2. This potentiation of carrageenan action is not modified when PG biosynthesis in leucocytes is inhibited by indomethacin or aspirin. It does not appear in rats previously treated by indomethacin or aspirin. 3. Our results suggest that rat polymorphonuclear leucocytes increase the inflammatory reaction, when they are stimulated by carrageenan, by the release of a phospholipase A2 activity which induces PG biosynthesis in rat paw tissues.

将多形核白细胞注射到大鼠爪中，它不会增强缓激肽的致水肿作用，但会增强λ-角叉菜胶的作用。2. 当白细胞中的前列腺素生物合成被吲哚美辛或阿司匹林抑制时，角叉菜胶作用的这种增强不会改变。在先前用吲哚美辛或阿司匹林处理过的大鼠中不会出现这种情况。3. 我们的结果表明，当大鼠多形核白细胞受到角叉菜胶刺激时，它们会通过释放磷脂酶A2活性来增加炎症反应，该活性会诱导大鼠爪组织中的前列腺素生物合成。