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[四乙铵及细胞外氯离子浓度降低对高钾溶液诱导的骨骼肌纤维膜去极化和收缩的影响]

[The effect of tetraethylammonium and the decrease in the extracellular chloride concentration on membrane depolarization and contraction of skeletal muscle fiber induced by a hyperpotassium solution].

作者信息

Brûlé G, Haudecoeur G

出版信息

Arch Int Physiol Biochim. 1982 Oct;90(3):145-58. doi: 10.3109/13813458209070565.

DOI:10.3109/13813458209070565
PMID:6186212
Abstract

1.--The tetraethylammonium (TEA) effects on K+ contracture and membrane depolarization are compared in both crab and frog skeletal muscle fibres. 2.--The mechanical tension of the contracture is reduced by the TEA in frog skeletal muscle fibre; it is increased in crab skeletal fibre. 3.--When no mechanical phenomenon is observed in frog skeletal muscle, the amplitude and the velocity of membrane depolarization induced by an increase of outward K+ concentration is reduced by the TEA. These effects are in opposition in crab muscle fibre. 4.--In crab muscle fibre, the results obtained tend to show that the C1-ions are not distributed on each side of the membrane according to Donnan equilibrium.

摘要
  1. 比较了四乙铵(TEA)对蟹和青蛙骨骼肌纤维钾离子挛缩及膜去极化的影响。

  2. TEA可降低青蛙骨骼肌纤维挛缩的机械张力;而在蟹骨骼肌纤维中则使其增加。

  3. 当青蛙骨骼肌未观察到机械现象时,TEA可降低因细胞外钾离子浓度升高引起的膜去极化的幅度和速度。这些效应在蟹肌纤维中则相反。

  4. 在蟹肌纤维中,所得结果倾向于表明氯离子并非按照唐南平衡分布于膜的两侧。

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1
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Arch Int Physiol Biochim. 1982 Oct;90(3):145-58. doi: 10.3109/13813458209070565.
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