大鼠肝细胞溶质酶将新合成的乳清酸盐快速转化为5-磷酸尿苷。
Rapid conversion of newly-synthesized orotate to uridine-5-monophosphate by rat liver cytosolic enzymes.
作者信息
Dileepan K N, Kennedy J
出版信息
FEBS Lett. 1983 Mar 7;153(1):1-5. doi: 10.1016/0014-5793(83)80107-0.
PMID:6186531
Abstract
It had been noted previously that the activity of mitochondrial dihydroorotate dehydrogenase was lower in crude tissue preparations containing cytosol than in isolated mitochondria. Closer examination reveals that the apparent lower enzyme activity is due to rapid conversion of newly-synthesized orotate to uridine-5-monophosphate by the cytosolic enzymes, orotate phosphoribosyltransferase and orotidylate decarboxylase.
摘要
先前已经注意到，在含有胞质溶胶的粗制组织制剂中，线粒体二氢乳清酸脱氢酶的活性低于分离的线粒体中的活性。进一步研究发现，酶活性明显较低是由于胞质酶乳清酸磷酸核糖基转移酶和乳清酸核苷酸脱羧酶将新合成的乳清酸迅速转化为5-磷酸尿苷所致。
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