Brohée D, Rondelez L, Bain H, de Maertelaer V
Gerontology. 1982 Nov-Dec;28(6):386-91. doi: 10.1159/000212561.
In a cross-sectional study, the amylase to creatinine clearance ratio (ACCR) was determined in 180 patients, age range 18-93 years. An inverse correlation was found between ACCR and creatinine clearance (r = -0.40, p less than 0.001) in keeping with the known inverse relationship between the sieving fraction of macromolecules and the glomerular filtration rate. The fractional clearance of amylase was not significantly affected by amylasemia nor by age when the creatinine clearance was also considered in a multiple regression analysis. No increase in ACCR was observed in patients with low molecular weight proteinuria or with induced urine dilution. The authors assume that the tubular reabsorption of amylase is minimal and that the enhancement of ACCR in the elderly mainly reflects modifications in the glomerular filtration dynamics.
在一项横断面研究中，对180名年龄在18至93岁之间的患者测定了淀粉酶与肌酐清除率比值（ACCR）。发现ACCR与肌酐清除率呈负相关（r = -0.40，p < 0.001），这与大分子筛分分数和肾小球滤过率之间已知的负相关关系一致。在多元回归分析中同时考虑肌酐清除率时，淀粉酶的分数清除率不受淀粉酶血症和年龄的显著影响。在低分子量蛋白尿患者或诱导尿液稀释的患者中未观察到ACCR升高。作者认为淀粉酶的肾小管重吸收极少，老年人ACCR的升高主要反映了肾小球滤过动力学的改变。
