肝素与大鼠的右旋糖酐类过敏反应

Heparin and the dextran anaphylactoid reaction in rats.

作者信息

West G B

出版信息

Int Arch Allergy Appl Immunol. 1983;70(4):373-5. doi: 10.1159/000233350.

Abstract

Injections of heparin had no effect on the dextran anaphylactoid reaction in rats but neutralised the inhibitory action both of protamine and of borate. Heparin, protamine, and borate did not modify the histamine or 5-hydroxytryptamine responses in rat paws and so their effects on dextran may be due to modification of the release mechanisms of these two amines from tissue mast cells.

摘要

注射肝素对大鼠右旋糖酐类过敏反应没有影响，但能中和鱼精蛋白和硼酸盐的抑制作用。肝素、鱼精蛋白和硼酸盐不会改变大鼠爪子中的组胺或5-羟色胺反应，因此它们对右旋糖酐的作用可能是由于改变了这两种胺从组织肥大细胞中的释放机制。