Schroeder W A, DeSimone J, Shelton J B, Shelton J R, Espinueva Z, Hall L, Zwiers D
J Biol Chem. 1983 Mar 10;258(5):3121-5.
The postnatal switch from hemoglobin (Hb) F to Hb A in the baboon (Papio cynocephalus) occurs somewhat more rapidly than in humans. Minor components which are related to Hb F and Hb A are also present and show reciprocal rise and fall. The baboon produces two types of gamma chain presumably from nonallelic genes. These have either an isoleucyl (I gamma) or a valyl (V gamma) residue in position 75. As in the human case with G gamma and A gamma chains, the ratio I gamma to V gamma chains changes during the postnatal switch. Production of Hb F in the baboon may be stimulated by phenylhydrazine or more effectively by 5-azacytidine. With phenylhydrazine, the ratio of I gamma to V gamma chains in the Hb F is the same as in the traces of Hb F in the juvenile or adult baboon. However, with 5-azacytidine, at least some of the Hb F that is produced probably has been synthesized with an I gamma to V gamma ratio that is present prenatally and in the newborn baboon.
狒狒（Papio cynocephalus）出生后从胎儿血红蛋白（Hb）F向成人血红蛋白（Hb）A的转换比人类发生得更快一些。与Hb F和Hb A相关的次要成分也存在，且呈现出相反的增减变化。狒狒可能从非等位基因产生两种类型的γ链。这些γ链在第75位要么含有异亮氨酰基（Iγ），要么含有缬氨酰基（Vγ）残基。与人类Gγ和Aγ链的情况一样，Iγ链与Vγ链的比例在出生后的转换过程中会发生变化。苯肼或更有效地通过5-氮杂胞苷可刺激狒狒产生Hb F。使用苯肼时，Hb F中Iγ链与Vγ链的比例与幼年或成年狒狒中微量Hb F中的比例相同。然而，使用5-氮杂胞苷时，至少所产生的一些Hb F可能是以产前和新生狒狒中存在的Iγ与Vγ比例合成的。
