脊髓灰质炎病毒中和主要抗原位点的定位及一级结构
Location and primary structure of a major antigenic site for poliovirus neutralization.
作者信息
Minor P D, Schild G C, Bootman J, Evans D M, Ferguson M, Reeve P, Spitz M, Stanway G, Cann A J, Hauptmann R, Clarke L D, Mountford R C, Almond J W
出版信息
Nature. 1983 Feb 24;301(5902):674-9. doi: 10.1038/301674a0.
We have determined a major antigenic site for virus neutralization on the capsid protein VP1 of poliovirus type 3. Antigenic mutant viruses selected for resistance to individual monoclonal antibodies had point mutations concentrated in a region 277-294 bases downstream from the start of the region of viral RNA coding for VP1. These findings provide the basis for an improved understanding of the molecular basis of virus neutralization.
我们已经确定了3型脊髓灰质炎病毒衣壳蛋白VP1上一个主要的病毒中和抗原位点。针对个别单克隆抗体具有抗性而筛选出的抗原突变病毒，其点突变集中在病毒RNA编码VP1区域起始点下游277 - 294个碱基的区域。这些发现为更好地理解病毒中和的分子基础提供了依据。
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