神经营养因子和血清白蛋白在营养不良小鼠中的轴突运输

Axonal transport of nerve growth factor and serum albumin in the dystrophic mouse.

作者信息

Rutherford P S, Boegman R J

出版信息

Neurosci Lett. 1982 Dec 31;34(3):209-13. doi: 10.1016/0304-3940(82)90177-x.

Abstract

Specific (nerve growth factor, NGF) and non-specific (serum albumin, BSA) uptake followed by retrograde axonal transport was studied in the sciatic nerves of normal (C57BL/6J) and dystrophic (dy2J/dy2J) mice. In the dystrophic mouse there was a significant decrease in the amount of NGF transported to dorsal root ganglia or BSA accumulating at a ligature placed on the sciatic nerve.

摘要

在正常（C57BL/6J）和营养不良（dy2J/dy2J）小鼠的坐骨神经中，研究了特异性（神经生长因子，NGF）和非特异性（血清白蛋白，BSA）摄取后逆行轴突运输的情况。在营养不良的小鼠中，运输到背根神经节的NGF量或在坐骨神经结扎处积累的BSA量显著减少。