Hill S W, Sercarz E E
Eur J Immunol. 1975 May;5(5):317-24. doi: 10.1002/eji.1830050506.
An immune response (Ir) gene is described which controls the ability of mice to respond to seven very closely related gallinaceous egg white lysozymes (GEL). This Ir-GEL gene locus is linked to the major histocompatibility locus of the mouse and operates at the level of the T cell. Responsiveness to the nonimmunogenic prototype hen egg white lysozyme (HEL) is dominant and is unrelated to age or sex of the animals, or to dose of protein administered. Ninety percent of C57BL/6 mice are absolute nonresponders to the nonimmunogenic lysozymes in complete Freund's adjuvant. The remaining mice exhibit severely restricted responses, with different anti-HEL clonotypes appearing in individual mice. The fine specificity of the Ir-GEL locus is evident in the discrimination of as few as two amino acid differences in a single region of the lysozyme molecule. This very precise distinction determines whether there will, or will not, be any response to the multideterminant molecule.
一种免疫反应（Ir）基因被发现，它能控制小鼠对七种密切相关的鸡卵清溶菌酶（GEL）产生反应的能力。这个Ir - GEL基因位点与小鼠的主要组织相容性位点相连，并在T细胞水平发挥作用。对非免疫原性原型鸡卵清溶菌酶（HEL）的反应性是显性的，且与动物的年龄、性别或所给予蛋白质的剂量无关。90%的C57BL/6小鼠对完全弗氏佐剂中的非免疫原性溶菌酶完全无反应。其余小鼠表现出严重受限的反应，在个体小鼠中出现不同的抗HEL克隆型。Ir - GEL位点的精细特异性在区分溶菌酶分子单个区域中仅两个氨基酸差异时就很明显。这种非常精确的区分决定了对多决定簇分子是否会产生反应。
