Fuller R W, Snoddy H D, Molloy B B
Res Commun Chem Pathol Pharmacol. 1982 Nov;38(2):349-52.
Cis and trans isomers of 1-amino-2-(p-chlorophenyl)cyclohexane, conformationally restricted analogs of p-chloroamphetamine, did not decrease brain serotonin and 5-hydroxyindoleacetic acid concentrations at i.p. doses of .05 and .1 mmole/kg in rats, doses at which p-chloroamphetamine itself decreased the concentrations of these 5-hydroxyindoles to half or less of their initial values. These analogs of p-chloroamphetamine, unlike several others studied previously, apparently lack the ability of the parent compound to inhibit serotonin uptake or synthesis or to release serotonin from intraneuronal granular stores.
1-氨基-2-（对氯苯基）环己烷的顺式和反式异构体，即对氯苯丙胺的构象受限类似物，在以0.05和0.1毫摩尔/千克的腹腔注射剂量给予大鼠时，并未降低脑内血清素和5-羟基吲哚乙酸的浓度，而在这些剂量下，对氯苯丙胺本身会将这些5-羟基吲哚的浓度降低至其初始值的一半或更低。与之前研究的其他几种类似物不同，这些对氯苯丙胺的类似物显然缺乏母体化合物抑制血清素摄取或合成或从神经内颗粒储存中释放血清素的能力。
