衣霉素可增强干扰素的抗病毒和抗细胞活性。

Tunicamycin enhances the antiviral and anticellular activity of interferon.

作者信息

Maheshwari R K, Sreevalsan T, Silverman R H, Hay J, Friedman R M

出版信息

Science. 1983 Mar 18;219(4590):1339-41. doi: 10.1126/science.6187067.

Abstract

The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.

摘要

用衣霉素处理可显著增强干扰素对病毒增殖和细胞生长的抑制作用。仅在包膜病毒中发现抗病毒活性增强，而在非出芽病毒中未发现。处理过的细胞的质膜变化可能解释了这种效应，因为包膜病毒作为终末步骤从细胞表面出芽。