Kluskens L, Lee W, Köhler H
Eur J Immunol. 1976 Jul;5(7):489-96. doi: 10.1002/eji.1830050712.
The antibodies to phosphorylcholine induced in BALB/c mice were isolated and studied with a variety of biochemical and immunochemical methods. Analysis of the idiotype and the hapten-binding specificities showed no differences to the phosphorylcholine-binding myeloma protein TEPC 15, indicating a high degree of homogeneity. However, disc electrophoresis, isoelectric focusing and amino acid composition data indicated large differences in the structure of anti-phosphorylcholine antibody and TEPC 15. By these criteria the anti-phosphorylcholine antibodies from BALB/c mice are of oligoclonal origin.
分离出在BALB/c小鼠中诱导产生的抗磷酸胆碱抗体，并用多种生化和免疫化学方法进行研究。对独特型和半抗原结合特异性的分析表明，其与磷酸胆碱结合的骨髓瘤蛋白TEPC 15没有差异，表明具有高度同质性。然而，圆盘电泳、等电聚焦和氨基酸组成数据表明，抗磷酸胆碱抗体和TEPC 15在结构上存在很大差异。根据这些标准，来自BALB/c小鼠的抗磷酸胆碱抗体起源于寡克隆。
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