神经管缺陷的产前诊断
Prenatal diagnosis of neural tube defects.
作者信息
Dembert M L, Harisiades J P
出版信息
Am Fam Physician. 1983 Feb;27(2):241-4.
PMID:6187201
Abstract
Neural tube defects are relatively common congenital malformations. An assay is available which permits prenatal screening of maternal serum for alpha-fetoprotein (AFP). Elevated AFP levels are associated with neural tube defects and other developmental abnormalities. Two positive blood tests indicate the need for ultrasonography. Further diagnostic testing of amniotic fluid for AFP and acetylcholinesterase levels may be necessary to confirm a neural tube defect.
摘要
神经管缺陷是相对常见的先天性畸形。有一种检测方法可用于对孕妇血清进行甲胎蛋白（AFP）的产前筛查。甲胎蛋白水平升高与神经管缺陷及其他发育异常有关。两次血液检测呈阳性表明需要进行超声检查。可能需要进一步检测羊水的甲胎蛋白和乙酰胆碱酯酶水平以确诊神经管缺陷。
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