Newbene P M, Nauss K M, de Camargo J L
Cancer Res. 1983 May;43(5 Suppl):2426s-2434s.
Lipotropes (choline, methionine, folic acid, and vitamin B12) are required for normal metabolic function at the cellular and subcellular levels. Deficiencies of any or all of them to a point of influence on methyl group metabolism has a profound effect on synthesis of cellular macromolecules and on cell proliferation. Lipotrope deficiency results in a diminished immunocompetence and an increased susceptibility to a number of types of cancer in experimental animals. A challenge now being addressed is to identify the linkage between lipotropes, the immune system, and cancer and to determine mechanisms which can be useful in cancer prevention.
促脂物质（胆碱、蛋氨酸、叶酸和维生素B12）是细胞和亚细胞水平正常代谢功能所必需的。它们中任何一种或全部缺乏至影响甲基代谢的程度，都会对细胞大分子的合成及细胞增殖产生深远影响。在实验动物中，促脂物质缺乏会导致免疫能力下降以及对多种癌症的易感性增加。目前正在应对的一项挑战是确定促脂物质、免疫系统和癌症之间的联系，并确定对癌症预防有用的机制。
