Sriram S, Schwartz G, Steinman L
Cell Immunol. 1983 Feb 1;75(2):378-82. doi: 10.1016/0008-8749(83)90335-0.
Intravenous administration of mouse myelin basic protein covalently coupled with chromic chloride to syngeneic spleen cells (MBP-SC) prevents the subsequent induction of experimental allergic encephalitis (EAE). Whereas 1 in 28 mice receiving MBP-SC developed EAE after immunization with mouse spinal cord homogenate (MSCH) and adjuvants, 16 out of 25 mice receiving ovalbumin-coupled spleen cells (OA-SC) had EAE following encephalitogenic challenge. The effect of administration of antigen-coupled spleen cells on in vitro proliferation responses is shown.
将与氯化铬共价偶联的小鼠髓鞘碱性蛋白静脉注射给同基因脾细胞（MBP-SC）可预防随后实验性变应性脑脊髓炎（EAE）的诱导。在用小鼠脊髓匀浆（MSCH）和佐剂免疫后，接受MBP-SC的28只小鼠中有1只发生EAE，而接受卵清蛋白偶联脾细胞（OA-SC）的25只小鼠中有16只在致脑炎攻击后发生EAE。显示了抗原偶联脾细胞给药对体外增殖反应的影响。
