Autret A, Laffont F, Roux S
Electroencephalogr Clin Neurophysiol. 1983 Apr;55(4):406-10. doi: 10.1016/0013-4694(83)90128-1.
Twenty-six patients suffering from partial epilepsy with complex seizures underwent polysomnographic recording. Paroxysmal activity (PA) densities in waking and sleep stages were assessed. Total PA densities of one night were found to be an increasing function of the seizure frequency in the previous period. Nineteen patients had more PA during sleep, 5 others in the waking state and the two remaining patients exhibited no differences in PA densities between sleep and waking. Nocturnal seizures were reported by patients showing the sleep PA increase pattern; they also used more anti-convulsants than patients showing the waking PA increase pattern. Differences in PA densities between these two groups were more pronounced in the more desynchronized (waking) and the more synchronized (stages 3 + 4) cortical states. The modulation by slow wave sleep stages was independent of, and superimposed on, the sleep/waking one.
26例患有部分性癫痫伴复杂发作的患者接受了多导睡眠图记录。评估了清醒和睡眠阶段的阵发性活动（PA）密度。发现一晚的总PA密度是前一时期癫痫发作频率的递增函数。19例患者在睡眠期间PA更多，另外5例在清醒状态下PA更多，其余2例患者睡眠和清醒时的PA密度无差异。报告夜间发作的患者呈现睡眠PA增加模式；他们使用的抗惊厥药物也比呈现清醒PA增加模式的患者更多。这两组之间的PA密度差异在皮质状态更不同步（清醒）和更同步（3 + 4期）时更为明显。慢波睡眠阶段的调节独立于睡眠/清醒调节，并叠加在其上。
