Klepac R
Endokrinologie. 1982 Nov;80(3):311-7.
Pregnant rats were treated with dexamethasone in drinking water (10 micrograms/ml) from the 15th to the 22nd day of pregnancy. Dexamethasone significantly reduced the weight of rat fetuses and concentration of DNA, RNA and proteins in fetal adrenal glands, liver, placenta, brain, kidneys, heart, lung, testes and pituitary from the 17th to the 22nd day of pregnancy. These data show that dexamethasone given to pregnant rat may lead to potentially deleterious effects on fetal rat development.
在妊娠第15天至第22天，给怀孕大鼠饮用含地塞米松（10微克/毫升）的水。从妊娠第17天至第22天，地塞米松显著降低了大鼠胎儿的体重以及胎儿肾上腺、肝脏、胎盘、脑、肾、心脏、肺、睾丸和垂体中DNA、RNA和蛋白质的浓度。这些数据表明，给怀孕大鼠使用地塞米松可能会对胎鼠发育产生潜在的有害影响。
