实验性变应性神经炎。对P2蛋白溴化氰肽的体液免疫和细胞免疫反应。

Experimental allergic neuritis. Humoral and cellular immune responses to the cyanogen bromide peptides of the P2 protein.

作者信息

Milek D J, Cunningham J M, Powers J M, Brostoff S W

出版信息

J Neuroimmunol. 1983 Apr;4(2):105-16. doi: 10.1016/0165-5728(83)90015-2.

Abstract

Lewis rats were immunized with P2 protein and peptides CN1, CN2 and CN3. In P2 immunized rats, antibody and cellular sensitivity to the P2 protein were seen prior to the appearance of clinical signs of EAN, during disease and during recovery. CN1 immunized rats had equal or more severe clinical and histological signs of EAN but lower antibody titers than P2 immunized animals. CN-1 elicited a greater blastogenic response in both P2 and CN-1 immunized animals. CN-2 and CN-3 immunized rats showed little clinical and histological evidence of EAN and no antibody. However, lymphocytes sensitive to the immunizing antigen and the P2 protein were present.

摘要

将Lewis大鼠用P2蛋白以及肽CN1、CN2和CN3进行免疫。在P2免疫的大鼠中，在出现实验性变态反应性神经炎（EAN）临床症状之前、疾病期间及恢复过程中，均可观察到对P2蛋白的抗体及细胞敏感性。与P2免疫的动物相比，CN1免疫的大鼠具有同等或更严重的EAN临床和组织学症状，但抗体滴度较低。CN - 1在P2免疫和CN - 1免疫的动物中均引发了更强的增殖反应。CN - 2和CN - 3免疫的大鼠几乎没有EAN的临床和组织学证据，也未产生抗体。然而，存在对免疫抗原和P2蛋白敏感的淋巴细胞。