• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SFR3-DR5, a monoclonal antibody with HLA-DR5 specificity.

作者信息

Radka S F, Machamer C, Cresswell P, Kostyu D D, Ward F E, Amos D B

出版信息

J Immunol. 1983 Apr;130(4):1863-6.

PMID:6187822
Abstract

We have developed a monoclonal antibody with HLA-DR5 serologic specificity. The antibody, SFR3-DR5, binds specifically to DR5-positive lymphoblastoid cell lines, and immunoprecipitates alpha- and beta-chains characteristic of DR antigens from them. Cytotoxic activity of the antibody segregates with the DR5-bearing haplotype in a family. The antibody reacted with the cells of 16 of 17 DR5 individuals and was negative on all DR5-negative cells tested. SFR3-DR5 reacted weakly with PWM-activated cells of the single DR5 individual whose B lymphocytes were unreactive with the monoclonal antibody by cytotoxicity. Possible interpretations of these results are discussed.

摘要

相似文献

1
SFR3-DR5, a monoclonal antibody with HLA-DR5 specificity.
J Immunol. 1983 Apr;130(4):1863-6.
2
Two-dimensional gel analysis of a second family of class II molecules by polymorphic HLA-DR4,5, and w9 monoclonal antibodies.利用多态性HLA-DR4、5和w9单克隆抗体对第二类分子的第二个家族进行二维凝胶分析。
J Immunol. 1984 May;132(5):2478-84.
3
Analysis of monoclonal antibodies reactive with human class II beta chains by two-dimensional electrophoresis and Western blotting.通过二维电泳和蛋白质免疫印迹法分析与人II类β链反应的单克隆抗体
Hum Immunol. 1984 Jul;10(3):177-86. doi: 10.1016/0198-8859(84)90038-7.
4
Identification of anti-DQ alloantisera correlated with DR5.
J Immunogenet. 1985 Dec;12(6):301-8.
5
Primary structural variation among serologically indistinguishable DS antigens: the MB3-bearing molecule in DR4 cells differs from the MB3-bearing molecule in DR5 cells.血清学上无法区分的DS抗原之间的主要结构变异：DR4细胞中携带MB3的分子与DR5细胞中携带MB3的分子不同。
J Immunol. 1984 Jul;133(1):1-3.
6
[Monoclonal antibodies to RPMI-1788 lymphoblastoid line cells].[针对RPMI-1788淋巴母细胞系细胞的单克隆抗体]
Eksp Onkol. 1986;8(6):41-6.
7
Production and characterization of monoclonal antibodies recognizing the alpha-chain subunits of human ia alloantigens.识别人类Ia同种异体抗原α链亚基的单克隆抗体的制备与特性分析
Immunology. 1983 Dec;50(4):613-24.
8
Inhibition of autologous mixed lymphocyte reaction by monoclonal antibodies specific for the beta chain of HLA-DR antigens.针对HLA - DR抗原β链的单克隆抗体对自身混合淋巴细胞反应的抑制作用。
Immunology. 1984 Sep;53(1):79-86.
9
A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones.一种大鼠抗小鼠T4单克隆抗体（H129.19）可抑制Ia反应性T细胞克隆的增殖，并在抗Ia细胞毒性T细胞克隆中区分出两个表型不同的亚群（T4+、Lyt-2,3-和T4-、Lyt-2,3+）。
J Immunol. 1984 Jun;132(6):2775-82.
10
Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens.针对单纯疱疹病毒感染细胞的人细胞毒性T细胞克隆。I. 由HLA II类MB和DR抗原限制的裂解作用
J Immunol. 1984 Jul;133(1):422-7.

引用本文的文献

1
Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection.负责针对黏膜和淋巴系统诺如病毒感染进行疫苗接种及清除感染的免疫机制。
PLoS Pathog. 2008 Dec;4(12):e1000236. doi: 10.1371/journal.ppat.1000236. Epub 2008 Dec 12.
2
Murine innate immune response to virulent toxigenic and nontoxigenic Bacillus anthracis strains.小鼠对强毒株产毒素和无毒株炭疽芽孢杆菌的天然免疫反应。
Infect Immun. 2007 Apr;75(4):1757-64. doi: 10.1128/IAI.01712-06. Epub 2007 Jan 22.
3
Antibody-independent control of gamma-herpesvirus latency via B cell induction of anti-viral T cell responses.
通过B细胞诱导抗病毒T细胞反应实现γ-疱疹病毒潜伏期的抗体非依赖性控制。
PLoS Pathog. 2006 Jun;2(6):e58. doi: 10.1371/journal.ppat.0020058. Epub 2006 Jun 23.
4
Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells.非传统的不依赖于MHC I类分子的CD8 T细胞对慢性γ-疱疹病毒感染的有效控制
PLoS Pathog. 2006 May;2(5):e37. doi: 10.1371/journal.ppat.0020037. Epub 2006 May 19.
5
Critical role of CD4 T cells in an antibody-independent mechanism of vaccination against gammaherpesvirus latency.CD4 T细胞在抗γ疱疹病毒潜伏感染的非抗体依赖疫苗接种机制中的关键作用。
J Virol. 2004 Jul;78(13):6836-45. doi: 10.1128/JVI.78.13.6836-6845.2004.
6
An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection.优化的CD4 T细胞反应可控制γ疱疹病毒的活跃感染和潜伏感染。
J Virol. 2004 Jul;78(13):6827-35. doi: 10.1128/JVI.78.13.6827-6835.2004.
7
Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome.II型裸淋巴细胞综合征多个基因互补组中抗原呈递细胞功能缺陷。
J Clin Invest. 1995 Jul;96(1):217-23. doi: 10.1172/JCI118023.
8
Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex.莫能菌素可阻止HLA-DR相关恒定链的N-连接和O-连接寡糖的末端糖基化，并抑制其与α-β链复合物的解离。
Proc Natl Acad Sci U S A. 1984 Mar;81(5):1287-91. doi: 10.1073/pnas.81.5.1287.
9
Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids.人T-B淋巴母细胞杂交体上T淋巴母细胞编码的HLA-DR抗原的表达
Immunogenetics. 1983;17(4):411-25. doi: 10.1007/BF00372459.
10
Molecular localization of human class II MT2 and MT3 determinants.人类II类金属硫蛋白2和金属硫蛋白3决定簇的分子定位
J Exp Med. 1984 Aug 1;160(2):472-93. doi: 10.1084/jem.160.2.472.