Oi V T, Herzenberg L A, Birshtein B K
J Immunol. 1983 Apr;130(4):1967-9.
A number of monoclonal antibodies are available that are reactive with distinct mouse immunoglobulin allotypic determinants. By determining which ones are present on a panel of hybrid IgG2b-IgG2a immunoglobulins, we have localized some of the allotypic determinants present on the IgG2a heavy chain of the "a" allotype (Igh-1a proteins). In particular, one group of determinants--Ig(1a)9.8 (20.6B8), 17.2 (20.19.2), and 14.4 (21.74.4)--has been placed in the CH2 domain. A second group--Ig(1a)8.3 (20.8.3), 21.2 (20.11.2), and 15.3 (21.66.3)--is located in a segment spanning the C terminal 8 residues of the CH2 domain and the complete CH3 domain.
有许多单克隆抗体可与不同的小鼠免疫球蛋白同种异型决定簇发生反应。通过确定一组杂交IgG2b-IgG2a免疫球蛋白上存在哪些抗体，我们已经定位了“a”同种异型（Igh-1a蛋白）的IgG2a重链上存在的一些同种异型决定簇。特别是，一组决定簇——Ig(1a)9.8（20.6B8）、17.2（20.19.2）和14.4（21.74.4）——已定位在CH2结构域中。第二组——Ig(1a)8.3（20.8.3）、21.2（20.11.2）和15.3（21.66.3）——位于跨越CH2结构域C末端8个残基和完整CH3结构域的一段区域中。
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