Askenase P W, Rosenstein R W, Ptak W
J Exp Med. 1983 Mar 1;157(3):862-73. doi: 10.1084/jem.157.3.862.
T cell-dependent activation of resident tissue mast cells is required for the elicitation of delayed-type hypersensitivity skin reactions in mice. A T cell-derived antigen-binding factor that transfers the ability to elicit an immediate hypersensitivity-like skin reaction is described and compared with a hybridoma IgE antibody. Both the T cell factor and IgE mediate reactions with increased vascular permeability and both are mast cell dependent, as they are inactive in two different types of mast cell deficient mice (W/Wv and Sl/Sld). The T cell factor was distinguished from IgE by affinity chromatography using specific anti-IgE and anti-factor antibodies and by a shorter duration of passive sensitization. The T cell factor is a suitable candidate for participation in the mechanism by which T cells activate mast cells in delayed-type hypersensitivity.
在小鼠中，迟发型超敏反应性皮肤反应的引发需要T细胞依赖性激活驻留组织肥大细胞。本文描述了一种T细胞衍生的抗原结合因子，它能够传递引发类似速发型超敏反应性皮肤反应的能力，并将其与杂交瘤IgE抗体进行了比较。T细胞因子和IgE均介导血管通透性增加的反应，且两者均依赖肥大细胞，因为它们在两种不同类型的肥大细胞缺陷小鼠（W/Wv和Sl/Sld）中均无活性。通过使用特异性抗IgE和抗因子抗体的亲和层析以及较短的被动致敏持续时间，将T细胞因子与IgE区分开来。T细胞因子是参与T细胞在迟发型超敏反应中激活肥大细胞机制的合适候选者。
