Parnes J R, Robinson R R, Seidman J G
Nature. 1983;302(5907):449-52. doi: 10.1038/302449a0.
beta 2-Microglobulin is the small, relatively invariant subunit of a family of cell-surface glycoproteins encoded within the major histocompatibility complex (MHC). Proteins associated with beta 2-microglobulin in the mouse include the classical transplantation antigens (H-2K, D and L), the thymus leukaemia antigen (TL) and certain haematopoietic cell differentiation antigens (Qa-1 and Qa-2). The genes encoding these proteins are members of a large, multigene family. In contrast, beta 2-microglobulin is encoded by a single copy gene on mouse chromosome 2 (refs 5, 6). We have shown that this gene consists of four coding blocks separated by three intervening sequences. We now demonstrate that the single beta 2-microglobulin gene is transcribed into at least two different size classes of mRNA that differ in the lengths of their 3' untranslated regions. We further show that three polyadenylation signals and a poly (A) tail are encoded at the 3' end of the gene.
β2-微球蛋白是主要组织相容性复合体（MHC）中编码的细胞表面糖蛋白家族的小的、相对恒定的亚基。在小鼠中与β2-微球蛋白相关的蛋白质包括经典移植抗原（H-2K、D和L）、胸腺白血病抗原（TL）和某些造血细胞分化抗原（Qa-1和Qa-2）。编码这些蛋白质的基因是一个大型多基因家族的成员。相比之下，β2-微球蛋白由小鼠2号染色体上的单拷贝基因编码（参考文献5、6）。我们已经表明，该基因由四个编码区组成，中间由三个间隔序列隔开。我们现在证明，单一的β2-微球蛋白基因转录成至少两种不同大小类别的mRNA，它们的3'非翻译区长度不同。我们进一步表明，该基因的3'端编码了三个聚腺苷酸化信号和一个聚（A）尾。
