Warnock M L, Prescott B T, Kuwahara T J
Scan Electron Microsc. 1982(Pt 2):845-57.
We compared the numbers of asbestos bodies in 2 histologic sections of lung from 25 subjects showing a wide range of total asbestos burden with the numbers of asbestos bodies and fibers (analyzed by electron diffraction and x-ray spectroscopy) extracted from the lung. We also compared the numbers of extracted asbestos bodies with the numbers of fibers in 24 other subjects. Histologic and extracted asbestos bodies were correlated best with total asbestos fibers and with amosite and crocidolite fibers, and not at all with chrysotile fibers. Nevertheless, the total fiber count could not be reliably estimated from the count of either histologic or extracted bodies. Although asbestos bodies appeared to be fairly uniformly distributed in these lungs, detection of early fibrosis or asbestosis required careful examination of all portions of the parenchyma. When we defined asbestos histologically as clusters of 3 or more asbestos bodies adjacent to areas of fibrosis, we found that subjects with asbestosis had more than 240,000 asbestos fibers/g of wet lung. The nature of the disease in lungs showing fibrosis and more than 240,000 fibers/g, but only isolated asbestos bodies, is uncertain.
我们比较了25名受试者肺组织学切片中石棉小体的数量，这些受试者的总石棉负荷范围很广，同时还比较了从肺中提取的石棉小体和纤维（通过电子衍射和X射线光谱分析）的数量。我们还比较了另外24名受试者中提取的石棉小体数量与纤维数量。组织学上的石棉小体和提取出的石棉小体与总石棉纤维、铁石棉和青石棉纤维的相关性最好，与温石棉纤维完全没有相关性。然而，无法根据组织学或提取的石棉小体数量可靠地估计总纤维计数。尽管石棉小体在这些肺中似乎分布相当均匀，但检测早期纤维化或石棉沉着病需要仔细检查实质的所有部分。当我们在组织学上把石棉定义为与纤维化区域相邻的3个或更多石棉小体的簇时，我们发现患有石棉沉着病的受试者每克湿肺中有超过240,000根石棉纤维。在显示纤维化且每克纤维超过240,000根但只有孤立石棉小体的肺中，疾病的性质尚不确定。
