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小鼠附睾中的乙醇脱氢酶。遗传变异与细胞定位。

Alcohol dehydrogenase in the mouse epididymis. Genetic variation and cellular localization.

作者信息

Spring K J, Elkington J S, Holmes R S

出版信息

Histochemistry. 1983;77(1):79-84. doi: 10.1007/BF00496638.

DOI:10.1007/BF00496638
PMID:6188725
Abstract

The cellular localization of alcohol dehydrogenase (ADH) in the mouse epididymis was investigated using differential substrate specificities and genetic variation as a means of distinguishing these enzymes histochemically in tissue sections. ADH-C2 exhibited high activity in BALB/c epididymis and was observed as a discrete zone within duct epithelial cells near the nuclei. This isozyme exhibited no detectable activity in C57BL/6J epididymis extracts or histochemical sections.

摘要

利用不同的底物特异性和基因变异作为在组织切片中对这些酶进行组织化学区分的手段，研究了酒精脱氢酶（ADH）在小鼠附睾中的细胞定位。ADH-C2在BALB/c附睾中表现出高活性，并在靠近细胞核的导管上皮细胞内观察到一个离散区域。这种同工酶在C57BL/6J附睾提取物或组织化学切片中未表现出可检测到的活性。

相似文献

1
Alcohol dehydrogenase in the mouse epididymis. Genetic variation and cellular localization.小鼠附睾中的乙醇脱氢酶。遗传变异与细胞定位。
Histochemistry. 1983;77(1):79-84. doi: 10.1007/BF00496638.
2
Genetic variation, cellular distribution and ontogeny of sorbitol dehydrogenase and alcohol dehydrogenase isozymes in male reproductive tissues of the mouse.小鼠雄性生殖组织中山梨醇脱氢酶和乙醇脱氢酶同工酶的遗传变异、细胞分布及个体发生
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Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3.小鼠乙醇脱氢酶同工酶的遗传学与个体发生：存在一个顺式作用调节基因（Adt-i）控制生殖组织中C2同工酶表达以及Adh-3与Adt-i在3号染色体上紧密连锁的证据
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Immunohistochemical localization of human liver alcohol dehydrogenase in liver tissue, cultured fibroblasts, and HeLa cells.人肝脏乙醇脱氢酶在肝组织、培养的成纤维细胞和HeLa细胞中的免疫组织化学定位。
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引用本文的文献

1
Genetic considerations in the effects of ethanol in mice. II. A trans-acting inducibility regulator(s) affecting alcohol dehydrogenase (ADH) activity.乙醇对小鼠影响中的遗传学考量。II. 一种影响乙醇脱氢酶（ADH）活性的反式作用诱导调节因子。
Biochem Genet. 1984 Aug;22(7-8):597-609. doi: 10.1007/BF00485847.
2
Genetics of ocular NAD+-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the mouse: evidence for genetic identity with stomach isozymes and localization of Ahd-4 on chromosome 11 near trembler.小鼠眼内NAD⁺依赖性乙醇脱氢酶和醛脱氢酶的遗传学：与胃同工酶基因同一性及Ahd - 4在11号染色体上震颤基因附近定位的证据
Biochem Genet. 1988 Apr;26(3-4):191-205. doi: 10.1007/BF00561459.

本文引用的文献

1
Mouse alcohol dehydrogenase isozymes: products of closely localized duplicate genes exhibiting divergent kinetic properties.小鼠乙醇脱氢酶同工酶：紧密定位的重复基因产物，表现出不同的动力学特性。
J Exp Zool. 1981 Aug;217(2):151-7. doi: 10.1002/jez.1402170202.
2
Alcohol dehydrogenase isozymes in the mouse: genetic regulation, allelic variation among inbred strains and sex differences of liver and kidney A2 isozyme activity.小鼠中的乙醇脱氢酶同工酶：基因调控、近交系间的等位基因变异以及肝脏和肾脏A2同工酶活性的性别差异
Anim Blood Groups Biochem Genet. 1982;13(2):97-108. doi: 10.1111/j.1365-2052.1982.tb01048.x.
3
Histochemical studies on genetical control of hormonal enzyme inducibility in the mouse. I. Non-specific esterase activity and regional histology of the epididymis.
小鼠激素酶诱导性遗传控制的组织化学研究。I. 附睾的非特异性酯酶活性及区域组织学
J Anat. 1978 Feb;125(Pt 2):247-65.
4
Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3.小鼠乙醇脱氢酶同工酶的遗传学与个体发生：存在一个顺式作用调节基因（Adt-i）控制生殖组织中C2同工酶表达以及Adh-3与Adt-i在3号染色体上紧密连锁的证据
Biochem Genet. 1979 Jun;17(5-6):461-72. doi: 10.1007/BF00498884.
5
Electrophoretic analyses of alcohol dehydrogenase, aldehyde dehydrogenase, aldehyde oxidase, sorbitol dehydrogenase and xanthine oxidase from mouse tissues.
Comp Biochem Physiol B. 1978;61(3):339-46. doi: 10.1016/0305-0491(78)90134-7.