Basrur V R, Knight P R
J Can Assoc Radiol. 1983 Mar;34(1):42-6.
Thirty-five patients with low-lying rectal adenocarcinoma have been treated with intracavitary radiation (Papillon's technique). Twenty-three were treated for cure and 12 for palliation. The indications for curative intracavitary radiation were mobile polypoid tumors, less than 3 cm in diameter, with Broder's Grades I and 2 differentiation lying less than 11 cm from the anal verge. Doses between 2 000 and 4 000 cGy were delivered to a total of 7 000 to 20 000 cGy with complete resolution of the tumors. Eighty-seven per cent in the curative group are alive and well up to 42 months after treatment with a minimum follow-up of six months. Of the 23 patients treated for cure, three patients had recurrences within 18 months of therapy. Two of the three patients are alive following surgery. The third patient died in the postoperative period. The results of intracavitary radiation are comparable to ablative surgery and avoid a permanent colostomy. Age, frailty, or other medical conditions do not preclude this treatment. Anesthesia and hospitalization are not required. This method can also be used for palliation of recurrent tumors and in patients who are unsuitable for surgery.
35例低位直肠腺癌患者接受了腔内放疗（帕皮永技术）。23例接受根治性治疗，12例接受姑息性治疗。根治性腔内放疗的指征为活动的息肉样肿瘤，直径小于3cm，布罗德分级为Ⅰ级和Ⅱ级，距肛缘小于11cm。给予2000至4000cGy的剂量，总量达7000至20000cGy，肿瘤完全消退。根治性治疗组87%的患者在治疗后42个月内存活且状况良好，最短随访6个月。在接受根治性治疗的23例患者中，3例在治疗后18个月内复发。3例患者中有2例术后存活。第3例患者在术后死亡。腔内放疗的结果与根治性手术相当，且避免了永久性结肠造口术。年龄、身体虚弱或其他医疗状况并不妨碍这种治疗。无需麻醉和住院。这种方法也可用于复发性肿瘤的姑息治疗以及不适于手术的患者。
