箭毒蛙毒素在体内会阻断慢速和逆向轴突运输。

Batrachotoxin blocks slow and retrograde axonal transport in vivo.

作者信息

Boegman R J, Riopelle R J

出版信息

Neurosci Lett. 1980 Jun;18(2):143-7. doi: 10.1016/0304-3940(80)90317-1.

Abstract

The accumulation of choline acetyltransferase (CAT) proximal to and nerve growth factor (NGF) distal to the intraneural site of tetrodotoxin (TTX) or batrachotoxin (BTX) injection in vivo was used to monitor orthograde and retrograde axonal transport. Orthograde axonal transport was blocked by BTX for up to 7-10 days while TTX had no effect. Similarly, retrograde transport of [125I]NGF was blocked by BTX and not by TTX.

摘要

体内注射河豚毒素（TTX）或蛙毒素（BTX）后，通过监测神经内注射部位近端的胆碱乙酰转移酶（CAT）和远端的神经生长因子（NGF）的积累来监测顺行和逆行轴突运输。BTX可阻断顺行轴突运输长达7 - 10天，而TTX则无此作用。同样，[125I]NGF的逆行运输被BTX阻断，而不被TTX阻断。