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大鼠脊髓神经节神经元的衰老:注射[3H]赖氨酸后的放射自显影研究

Ageing of the spinal ganglion neurons in the rat: a radioautographic study following injection of [3H]lysine.

作者信息

van den Bosch de Aguilar P, Vanneste J

出版信息

Neurosci Lett. 1980 Jul;18(3):225-30. doi: 10.1016/0304-3940(80)90289-x.

DOI:10.1016/0304-3940(80)90289-x
PMID:6189022
Abstract

After administration of [3H]lysine to 3- and 24-month-old rats, radioautography demonstrates a significantly less important uptake in the A-type spinal ganglion neurons and in the old animals. This is in agreement with the existence of at least two functional categories of neurons in the spinal ganglion and suggests that protein synthesis is diminished in the old animals. The very fact that incorporation varies between animals of the same age sustains the hypothesis according to which amplitude of ageing is essentially an individual physiological-dependent process.

摘要

给3个月和24个月大的大鼠注射[3H]赖氨酸后,放射自显影显示,A 型脊髓神经节神经元以及老年动物体内的摄取量明显减少。这与脊髓神经节中至少存在两种功能类别的神经元相一致,并表明老年动物体内的蛋白质合成减少。同一年龄的动物之间掺入情况存在差异这一事实支持了如下假设,即衰老程度本质上是一个依赖个体生理状况的过程。

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Neurosci Lett. 1980 Jul;18(3):225-30. doi: 10.1016/0304-3940(80)90289-x.
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