Walker P R, Sikorska M, Whitfield J F
J Cell Physiol. 1978 Jan;94(1):87-91. doi: 10.1002/jcp.1040940111.
There is a marked increase in the concentration of putrescine during the first ten hours following partial hepatectomy in rats. The concentration of spermidine also increases but to a smaller degree. Putrescine levels return to normal between 10 and 24 hours after the operation, whereas the increased spermidine level is maintained. The production of putrescine and spermidine appears to be initiated by the induction of ornithine decarboxylase which shows a single peak of activity at four hours after hepatectomy. The activity of S-adenosylmethionine decarboxylase shows little change following hepatectomy. The changes in polyamine levels and the activities of the enzymes of polyamine metabolism are not affected by thyroparathyroidectomy 72 hours prior to hepatectomy. Thus although these hypocalcemic conditions considerably reduce and delay DNA synthesis and mitosis, the prereplicative changes in polyamine metabolism still occur. These data suggest that the hepatocytes in hypocalcemic animals have become activated and moved to an advanced stage of prereplicative development before being blocked.
大鼠部分肝切除术后的最初10小时内，腐胺浓度显著升高。亚精胺浓度也升高，但幅度较小。腐胺水平在术后10至24小时恢复正常，而升高的亚精胺水平则维持不变。腐胺和亚精胺的产生似乎是由鸟氨酸脱羧酶的诱导引发的，该酶在肝切除术后4小时出现单一活性高峰。肝切除术后，S-腺苷甲硫氨酸脱羧酶的活性变化不大。肝切除术前72小时进行甲状旁腺切除术，对多胺水平的变化以及多胺代谢酶的活性没有影响。因此，尽管这些低钙血症情况会显著减少并延迟DNA合成和有丝分裂，但多胺代谢的复制前变化仍然会发生。这些数据表明，低钙血症动物的肝细胞在被阻断之前已被激活并进入复制前发育的晚期阶段。
