Welsmann K, Kvist N, Kobayasi T
Acta Derm Venereol. 1983;63(2):143-6.
A 5 1/2-year-old girl with idiopathic intestinal pseudo-obstruction became severely depleted of zinc during total parenteral nutrition and developed a vesico-bullous rash on face, hands and feet such as is seen in acrodermatitis enteropathica. Light and electron microscopy of a bullous lesion on one foot revealed a pronounced extracellular edema with cyst and cleft formation in the deep part of the epidermis. A few acantholytic cells were seen. In the electron microscope degenerate keratinocytes showed multiple vacuoles in the dark cytoplasm and slender, finger-like protrusions. Desmosomes were few. The basal lamina was well-preserved forming deep invaginations, which may serve to distinguish the condition from other bullous diseases of the skin.
一名5岁半患有特发性肠道假性梗阻的女孩在全胃肠外营养期间锌严重缺乏，并在面部、手部和足部出现了类似肠病性肢端皮炎的水疱大疱性皮疹。对一只脚上的一个水疱性病变进行光镜和电镜检查发现，表皮深部有明显的细胞外水肿，伴有囊肿和裂隙形成。可见少数棘层松解细胞。在电子显微镜下，退变的角质形成细胞在深色细胞质中显示多个空泡以及细长的指状突起。桥粒很少。基底层保存完好，形成深的内陷，这可能有助于将这种情况与其他皮肤大疱性疾病区分开来。
