Neilson J P, Hood V D, Cupples W
Acta Genet Med Gemellol (Roma). 1982;31(3-4):229-33. doi: 10.1017/s0001566000008333.
Five cases of twin pregnancy associated with elevated maternal serum alpha-fetoprotein levels are presented. In each instance an abnormality was detected by ultrasound examination--in four cases this represented anomalous development of one or both fetuses: discordant anencephaly; a monozygotic heterokaryotypic twin pregnancy with coexistent Turner's syndrome and intrauterine death; concordant body-stalk syndrome; and fetal exomphalos together with an acardiac monster. In the remaining case, there had been an intrauterine death of one of the twins. Ultrasound examination proved valuable in all instances; three pregnancies were terminated and single healthy infants were delivered from each of the other two pregnancies.
本文报告了5例双胎妊娠合并孕妇血清甲胎蛋白水平升高的病例。每例均经超声检查发现异常——4例表现为一个或两个胎儿发育异常：不一致性无脑畸形；单卵异核型双胎妊娠合并特纳综合征及宫内死亡；一致性体蒂异常综合征；胎儿脐膨出合并无心畸形。其余1例为双胎之一宫内死亡。超声检查在所有病例中均显示出价值；3例妊娠终止，另外2例妊娠各分娩出1名健康婴儿。
