Elhilali M, Lehoux J G, Carmel M, Madarnas P, Mongeau C, Beauchesne C, Tétreault L, Bénard B
Arch Androl. 1983 Mar;10(1):21-7. doi: 10.3109/01485018308990165.
The objective of this study was to determine the nuclear dihydrotestosterone (DHT) nuclear receptors content in tissues of normal prostate, benign prostatic hypertrophy (BPH), and prostatic cancer. We also attempted to correlate this with the histological pattern of these tissues. Specimens were obtained from five normal subjects, 24 BPH, and 19 prostatic cancer patients. Nuclear receptors content was determined. All histological sections were reviewed by three independent pathologists. The criteria for the quantitative analysis were the degree of cellularity and the stromal content. The mean receptor content was not significantly different between neoplastic tissue (52.6 fmol/mg protein) and hyperplastic tissue (38.9 fmol/mg protein). The number of binding sites in normal prostatic tissue was 8.5 fmol/mg protein. The correlation between the degree of cellularity and DHT receptors showed no significant difference for both BPH, as well as prostatic cancer. Similar results were obtained when stromal content was compared.
本研究的目的是测定正常前列腺、良性前列腺增生（BPH）和前列腺癌组织中的核二氢睾酮（DHT）核受体含量。我们还试图将此与这些组织的组织学模式相关联。标本取自5名正常受试者、24例BPH患者和19例前列腺癌患者。测定核受体含量。所有组织学切片均由三名独立的病理学家进行评估。定量分析的标准是细胞密度和间质含量。肿瘤组织（52.6 fmol/mg蛋白质）和增生组织（38.9 fmol/mg蛋白质）之间的平均受体含量无显著差异。正常前列腺组织中的结合位点数为8.5 fmol/mg蛋白质。对于BPH和前列腺癌，细胞密度与DHT受体之间的相关性均无显著差异。比较间质含量时也得到了类似结果。
