与胃酸缺乏（恶性贫血）相关的胃类癌（胃泌素瘤）。

Gastric carcinoid (gastrinoma) associated with achlorhydria (pernicious anemia).

作者信息

Morgan J E, Kaiser C W, Johnson W, Doos W G, Dayal Y, Berman L, Nabseth D

出版信息

Cancer. 1983 Jun 15;51(12):2332-40. doi: 10.1002/1097-0142(19830615)51:12<2332::aid-cncr2820511228>3.0.co;2-i.

DOI:10.1002/1097-0142(19830615)51:12<2332::aid-cncr2820511228>3.0.co;2-i

Abstract

This report presents a case of multicentric gastric carcinoid (gastrin containing) tumors of the fundus associated with achlorhydria and pernicious anemia. It is suggested that stimulation of the antral G cells and possibly fundic argyrophilic cells by achlorhydria associated with atrophic gastritis may lead to hyperplasia, and eventually to neoplasia in the latter, in the form of gastric carcinoid with gastrin production.

摘要

本报告介绍了一例胃底多中心性类癌（含胃泌素）肿瘤，伴有胃酸缺乏和恶性贫血。有人认为，与萎缩性胃炎相关的胃酸缺乏刺激胃窦G细胞以及可能的胃底嗜银细胞，可能导致增生，最终使后者发生肿瘤形成，表现为产生胃泌素的胃类癌。