Constantinidis J, Bouras C, Richard J
Clin Neuropathol. 1983;2(2):47-54.
In Huntington's disease, there is a decrease of the neuropeptides, substance P, enkephalins, and cholecystokinin in the striatonigral system, whereas in Parkinson's disease an increase of substance P is found in the substantia nigra. Several neuropeptides should be involved in Alzheimer's disease: substance P, endorphins, vasopressin, ACTH, somatostatin, vasoactive intestinal peptide, cholecystokinin, neurotensin, delta sleep-inducing peptide. Alterations of substance P, vasoactive intestinal peptide, cholecystokinin, somatostatin, and endorphins may be related to the pathophysiology of schizophrenia. Delta sleep-inducing peptide may interfere in addiction pathology.
在亨廷顿舞蹈症中，纹状体黑质系统中的神经肽、P物质、脑啡肽和胆囊收缩素减少，而在帕金森病中，黑质中发现P物质增加。几种神经肽与阿尔茨海默病有关：P物质、内啡肽、血管加压素、促肾上腺皮质激素、生长抑素、血管活性肠肽、胆囊收缩素、神经降压素、δ睡眠诱导肽。P物质、血管活性肠肽、胆囊收缩素、生长抑素和内啡肽的改变可能与精神分裂症的病理生理学有关。δ睡眠诱导肽可能干扰成瘾病理。
